|
T25487 |
Haloperidol decanoate
|
KD 16,KD-136,KD 136,Neoperidole,Haldol |
Others
|
|
Haloperidol decanoate (KD 16) is a typical antipsychotic agent utilized as maintenance treatment for schizophrenia and mood disorders formulated as an ester for intramuscular injection. |
|
T5858 |
Sertindole
|
Lu 23-174 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Autophagy
|
|
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
|
T13620 |
Clothixamide
|
Clotixamide |
Others
|
|
Clothixamide（Clotixamide） is a thioxanthene derivative with antipsychotic activity. |
|
T28267 |
ORM-10921
|
ORM10921,ORM 10921 |
Adrenergic Receptor
|
|
ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies. |
|
T28231 |
Olanzapine N-Oxide
|
|
Others
|
|
Olanzapine N-Oxide is a metabolite of Olanzapine which shows antipsychotic activity. |
|
T10989 |
Dehydroaripiprazole
|
OPC-14857,DM-14857 |
5-HT Receptor
|
|
Dehydroaripiprazole (DM-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroaripiprazole. Dehydroaripiprazole has anti... |
|
T23900 |
Clothiapine
|
S-805C,HF2159,HF 2159,HF-2159,LW 2159 |
5-HT Receptor
|
|
Clothiapine (HF 2159) is an atypical antipsychotic agent with potent anti 5-hydroxytryptaminergic and serotonergic activity, which has been used in the study of schizophrenia. |
|
T20797 |
NE-100 hydrochloride
|
NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl |
Sigma receptor
|
|
NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death. |
|
T68047 |
Clopipazan
|
|
Others
|
|
Clopipazan is an antipsychotic and antidepressant compound.Clopipazan has sedative and anxiolytic activity, possibly due to selective GABergic blockade of certain interneurons. |
|
T1740 |
BD-1047 dihydrobromide
|
BD1047.2HBr |
Sigma receptor
|
|
BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia. |
|
T0031L |
Ziprasidone hydrochloride
|
CP-88059 hydrochloride,CP-88059,Ziprasidone HCl |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
|
T39211 |
PD 144418 oxalate
|
|
Sigma receptor
|
|
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes.... |
|
T0766 |
Promazine hydrochloride
|
Romtiazin hydrochloride,Sinophenin hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
|
|
Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as ... |
|
T24885L |
Tiaspirone hydrochloride
|
BMY-13859 hydrochloride,Tiaspirone hydrochloride（87691-91-6 Free base) |
Dopamine Receptor
,
5-HT Receptor
|
|
Tiaspirone hydrochloride (BMY-13859 hydrochloride) exhibits antipsychotic activity. Tiaspirone hydrochloride influences the electrophysiological activity of dopaminergic neurons in the substantia nigra zona compacta (A9 ... |
|
T0031 |
Ziprasidone hydrochloride monohydrate
|
CP 88059 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity. |
|
T23854 |
Carbidine
|
Carbidine dihydrochloride,Karbidin,Carbidin,Karbidine |
Others
|
|
Carbidine (Carbidin) is a derivative of gamma-carboline, an atypical antipsychotic drug. It reduces the inhibitory effect of DA on the 3H-DA release from synaptosomes of the nucleus accumbens septi and on the activity of... |
|
T0031L2 |
Ziprasidone
|
Geodon,Zeldox,CP-88059 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Ziprasidone (Geodon) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
|
T23318L |
SB 258585
|
|
5-HT Receptor
|
|
SB 258585 is a selective 5-HT6 receptor antagonist.SB 258585 has a high affinity for individual receptor populations in cell lines with human recombinant 5-HT6 receptors.SB 258585 can be used to label both recombinant an... |
|
T0455 |
Clozapine
|
HF 1854,LX 100-129 |
Dopamine Receptor
,
Adrenergic Receptor
,
AChR
|
|
Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a... |
|
T21368 |
Thioproperazine
|
Megeptil,Sulfenazin,Cephalmin,Majeptyl,Vontil,Mazeptyl |
|
|
Thioproperazine is a drug with the activity of antipsychotic. |
|
T26909 |
Bromerguride
|
|
|
|
Bromerguride is a dopamine antagonist with the activity of antipsychotic. |
|
T11435 |
GlyT1 Inhibitor 1
|
|
Others
|
|
GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor (IC50: 38 nM for rGlyT1) with antipsychotic activity. |
|
T29009 |
Trifluoperazine N-Glucuronide
|
|
|
|
Trifluoperazine N-Glucuronide is a metabolite of Trifluoperazine with antidepressant and antipsychotic activity. |
|
T35307 |
Zicronapine
|
Lu-31130,Lu31-130,Lu 31130,Lu 31-130,Lu31130,Lu-31-130 |
|
|
Zicronapine( LU 31-130) is an atypical antipsychotic. Zicronapine has monoaminergic activity and multi-receptor properties. It has shown effective antagonism against dopamine D1, D2, and serotonin 5HT2A receptors in vitr... |
|
T39010 |
Xanomeline tartrate
|
LY 246708 tartrate,Xanomeline tartrate |
|
|
Xanomeline (LY 246708), a potent agonist of muscarinic M1/M4 receptors, exhibits antipsychotic-like activity and enhances neuronal excitability. It is a valuable compound for studying schizophrenia. |
|
T13400 |
Ziprasidone D8
|
CP-88059 D8 |
Others
|
|
Ziprasidone D8 is deuterium labeled Ziprasidone, which is a antagonist of combined 5-HT (serotonin) and dopamine receptor and exhibits potent effects of antipsychotic activity. |
|
T15026 |
Cyamemazine
|
|
5-HT Receptor
|
|
Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM) and 5-HT2C (Ki: 75 nM) receptors antagonist with antipsych... |
|
T16445 |
PD 144418
|
|
Sigma receptor
|
|
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for σ1 and σ2 respectively). It shows devoid of any significan... |
|
T81336 |
PZ-1190
|
|
Dopamine Receptor
|
|
PZ-1190, a multitarget ligand for serotonin and dopamine receptors, exhibits potential antipsychotic activity in rodents [1]. |
|
T73961 |
Ziprasidone amino acid
|
|
|
|
Ziprasidone amino acid (Ziprasidone Impurity C), an impurity found in Ziprasidone, functions as a combined 5-HT (serotonin) and dopamine receptor antagonist. This compound demonstrates significant antipsychotic activity ... |
|
T79802 |
5-HT2C agonist-3
|
|
5-HT Receptor
|
|
5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced hyperactivity [1]. |
|
T62082 |
FPPQ
|
|
|
|
FPPQ is a dual antagonist of the 5-HT3 and 5-HT6 receptors with Ki values of 0.9 nM and 3 nM, respectively, and exhibits antipsychotic and pro-cognitive activity. |
|
T78514 |
Timiperone
|
|
Dopamine Receptor
|
|
Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior. It is utilized in the research of schizophrenia [1] [2] [3]. |
|
T79803 |
5-HT2C agonist-3 free base
|
|
5-HT Receptor
|
|
5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-induced hyperactivity [1]. |
|
T38221 |
N,N-Dipropyldopamine (hydrobromide)
|
|
|
|
N,N-Dipropyldopamine is a dopamine receptor agonist.1,2,3 It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum of reserpinized rats (ED50s = 25 and 20 μmol/kg, respectively), as well as re... |
|
T69129 |
Clozapine HCl
|
|
|
|
Clozapine HCl is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serot... |
|
T61915 |
Thiethylperazine
|
|
|
|
Thiethylperazine is a phenothiazine derivative. Thiethylperazine is a histamine H1 receptor and dopamine D2 receptor antagonist with oral activity. Thiethylperazine is also a selective ABCC1 activator, which can reduce a... |
